Resident Evil 5, known in Japan as Biohazard 5 (バイオハザード5?), is an action-adventure third-person shooter video game developed and published by Capcom. The game, the seventh installment in the Resident Evil series, was released on March 5, 2009 in Japan and on March 13, 2009 in North America and Europe for the PlayStation 3 and Xbox 360 and September 2009 for Microsoft Windows.

The plot of Resident Evil 5 revolves around Chris Redfield and Sheva Alomar's investigation of a terrorist threat in Kijuju, a fictional region in Africa. Chris soon finds he has to confront his past in the shape of old enemy Albert Wesker.

The game was announced in 2005, the same year as its predecessor Resident Evil 4 was released, with several staff members from that game and the original Resident Evil being involved. Employed in the game for the first time was the use of motion capture for the cutscenes, making the characters' movements more realistic. Its gameplay was kept similar to the previous installment, though the game's producer Jun Takeuchi said that some thematics from the original game were used.

Resident Evil 5 was released on all its platforms in 2009, eventually outselling its predecessor and becoming the best-selling single game of the franchise. On the whole, critical reception was positive, despite allegations of racist attitudes in the trailer shown at the 2007 E3 event.